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SARMs Database: Every Compound Compared

Half-life, research stage, human studies, WADA status, testosterone suppression and strength of evidence for every compound we cover, each value linked to its source.

Key takeaways

  • Every compound we cover in one table: SARMs, MK-677, cardarine, PCT drugs and research peptides.
  • Each value (half-life, research stage, human studies, WADA status, suppression, evidence) links to a checked source.
  • No SARM is an approved medicine anywhere; ostarine has the most human trial data.
  • Where no reliable human data exists, the database says "not established" instead of guessing.

The Sarmguide database lists every compound we cover: SARMs such as ostarine, LGD-4033 and RAD-140, the compounds often sold next to them (MK-677 and cardarine), the drugs studied for post-cycle therapy, and research peptides. Each row shows what published human studies found, and every value links to its source on the compound’s own page.

Search by name or alias (MK-2866, ligandrol, ibutamoren), filter by type or by what a compound was researched for, and select a column heading to sort.

Compound database (select a column heading to sort)
AC-262AC-262536, AC-262,536SARM—Preclinical0Prohibited at all timesModerate animal dataVery limited
ACP-105ACP105SARM—Preclinical0Prohibited at all timesNot measuredVery limited
AnastrozoleArimidexPCT & hormonal~2–2.1 daysApproved396 (PubMed trial records)Prohibited at all timesNone found human dataModerate
Andarine (S4)S-4, S4SARM—Preclinical0Prohibited at all timesModerate animal dataVery limited
BPC-157BPC 157, Body Protection Compound-157Peptide—Phase 25Prohibited at all timesNot measuredVery limited
CardarineGW501516, GW-501516Other—Phase 24Prohibited at all timesNot measuredModerate
CJC-1295CJC 1295, CJC-1295 with DACPeptide~5.8–8.1 daysPhase 23Prohibited at all timesNot measuredLimited
ClomipheneClomifene, Clomiphene citratePCT & hormonal~5–24 hApproved815 (PubMed trial records)Prohibited at all timesNone found human dataModerate
EnclomipheneEnclomifene, Enclomiphene citratePCT & hormonal~8–10 hPhase 37 (PubMed trial records)Prohibited at all timesNone found human dataModerate
GHK-CuCopper peptide, Copper tripeptide-1Peptide——3Not named – uncertain (may fall under S0)Not measuredLimited
IGF-1 LR3Long R3 IGF-1, LR3IGF-IPeptide—Preclinical0Prohibited at all timesNot measuredVery limited
IpamorelinIpamorelin acetateGH secretagogue~2 hPhase 22Prohibited at all timesNot measuredLimited
LGD-4033Ligandrol, VK5211SARM~24–36 hPhase 22Prohibited at all timesMarked human dataModerate
MK-677Ibutamoren, Ibutamoren mesylateGH secretagogue—Phase 317Prohibited at all timesMild human dataStrong
MOTS-cMOTS-C, Mitochondrial open reading frame of the 12S rRNA-cPeptide—Preclinical0Prohibited at all timesNot measuredVery limited
OstarineEnobosarm, MK-2866SARM~14–24 hPhase 38Prohibited at all timesModerate human dataStrong
RAD-140Testolone, VosilasarmSARM~45 hPhase 1/21Prohibited at all timesModerate animal dataLimited
RAD-150TLB-150, RAD150SARM—Preclinical0Prohibited at all timesNot measuredVery limited
S-23S23, SARM S-23SARM—Preclinical0Prohibited at all timesModerate animal dataVery limited
SR9009Stenabolic, SR-9009Other—Preclinical0Prohibited at all timesNot measuredVery limited
TamoxifenTamoxifen citrate, NolvadexPCT & hormonal~5–7 daysApproved2,342 (PubMed trial records)Prohibited at all timesNone found human dataModerate
TB-500TB500, Thymosin beta-4 fragment (17-23)Peptide—Preclinical0Prohibited at all timesNot measuredVery limited
TesamorelinEgrifta, Egrifta SVPeptide~8–11 minApproved15 (PubMed trial records)Prohibited at all timesNone found human dataStrong
YK-11YK11, MyostineSARM—Preclinical0Prohibited at all timesNot measuredVery limited

Suppression: "human data" means testosterone was measured in people; "animal data" means the score rests on animal studies because it was not measured in men; "None found" means it was measured and did not fall; "Not measured" means there are no data, which is not the same as no suppression.

How studies are counted: "Human studies" is the number of published human treatment studies we found and read for a compound (trials and other studies that gave it to people). Animal, cell and anti-doping excretion studies are not counted, and a single case report is not a study. Searches of PubMed and ClinicalTrials.gov were last run on 30 Oct 2026.

† For drugs with hundreds of trials (Anastrozole, Clomiphene, Enclomiphene, Tamoxifen, and Tesamorelin), the number is the PubMed records typed Clinical Trial or RCT that mention the drug, not studies read one by one. The count is a floor, not a census, and not a measure of quality.

Every value links to its source on the compound page. Data last checked 30 Oct 2026.

What each column means

Column What it shows
Half-life How long it takes for blood levels to fall by half in people, as a range where studies differ. A dash means we found no human study that measured it. For MK-677, for example, the only half-life figures we found online came from sellers and blogs, so we leave it blank.
Research stage The furthest phase of human trials the compound reached (“Phase 1/2” when its furthest trial is a combined phase 1/2 trial). “Approved” means it is an approved medicine somewhere, usually for a different use: tamoxifen and anastrozole for breast cancer, clomiphene for ovulation problems in women, tesamorelin for abdominal fat in HIV.
Human studies The number of published human treatment studies we found and read. Animal, cell and anti-doping excretion studies are not counted, and a single case report is not a study. For drugs with hundreds of trials (marked †), it is the number of PubMed records typed Clinical Trial or RCT. It is a floor, not a census: for ostarine we count 8 trials with results, while the developer states its safety database covers 27 trials (a company figure). The searches were last run on 30 October 2026.
WADA Status on the 2026 World Anti-Doping Agency Prohibited List. See SARMs and WADA for the list sections.
Suppression A Sarmguide score from 0 to 3 (none found, mild, moderate, marked) for how much natural testosterone fell in the cited studies, marked “human data” when it was measured in people and “animal data” when it rests on animal studies. “Not measured” means there are no data, which is not the same as “none found”.
Evidence A Sarmguide score from 0 to 3 (very limited, limited, moderate, strong) for how much human research exists and how good it is. Animal-only compounds score lowest; compounds with large controlled trials score highest.

How the data is collected

Every value comes from a source we opened and read: PubMed records and full papers, ClinicalTrials.gov results, drug labels on DailyMed, regulator documents (FDA, EMA, TGA, Health Canada) and the WADA Prohibited List. Each finding carries an evidence label (trial, case report, animal, lab analysis, regulator review) so you can see what kind of study it rests on. When no reliable source exists, the database says “not established” instead of guessing. Forum reports and seller claims are not used as evidence. The full process is on our methodology page.

What the database cannot tell you

  • Research doses are not product doses. Trials used small, measured doses (ostarine at 0.1 to 3 mg a day in a trial in older adults, for example). Products sold online often do not match their label: in a 2017 analysis of 44 products sold as SARMs, only 52% contained a SARM and only 41% held the amount on the label (Van Wagoner 2017).
  • Trials were short and small. Most lasted weeks to a few months, in older adults or patients. A 2026 review notes that serious harms such as cholestatic liver injury appear mostly in case reports of higher-dose, stacked and unmonitored use (Adolf 2026).
  • No SARM is an approved medicine. None has been approved in more than 25 years of development (Adolf 2026), and the FDA says products sold as SARMs are unapproved drugs, not dietary supplements (FDA).

Fact sheets

Every compound in the table has a fact sheet with its studies, side effects, charts and sources:

How far each compound got in research

Furthest stage of human clinical trials reached (Preclinical = animal or cell studies only; Approved = approved as a medicine somewhere).
How far each compound got in clinical researchAnastrozole: Approved (396 human studies); Clomiphene: Approved (815 human studies); Tamoxifen: Approved (2342 human studies); Tesamorelin: Approved (15 human studies); Enclomiphene: Phase 3 (7 human studies); MK-677: Phase 3 (17 human studies); Ostarine: Phase 3 (8 human studies); BPC-157: Phase 2 (5 human studies); Cardarine: Phase 2 (4 human studies); CJC-1295: Phase 2 (3 human studies); Ipamorelin: Phase 2 (2 human studies); LGD-4033: Phase 2 (2 human studies); RAD-140: Phase 1/2 (1 human study); AC-262: Preclinical (0 human studies); ACP-105: Preclinical (0 human studies); Andarine (S4): Preclinical (0 human studies); IGF-1 LR3: Preclinical (0 human studies); MOTS-c: Preclinical (0 human studies); RAD-150: Preclinical (0 human studies); S-23: Preclinical (0 human studies); SR9009: Preclinical (0 human studies); TB-500: Preclinical (0 human studies); YK-11: Preclinical (0 human studies)PreclinicalPhase 1Phase 2Phase 3ApprovedAnastrozoleAnastrozole: Approved (396 human studies)ApprovedClomipheneClomiphene: Approved (815 human studies)ApprovedTamoxifenTamoxifen: Approved (2342 human studies)ApprovedTesamorelinTesamorelin: Approved (15 human studies)ApprovedEnclomipheneEnclomiphene: Phase 3 (7 human studies)Phase 3MK-677MK-677: Phase 3 (17 human studies)Phase 3OstarineOstarine: Phase 3 (8 human studies)Phase 3BPC-157BPC-157: Phase 2 (5 human studies)Phase 2CardarineCardarine: Phase 2 (4 human studies)Phase 2CJC-1295CJC-1295: Phase 2 (3 human studies)Phase 2IpamorelinIpamorelin: Phase 2 (2 human studies)Phase 2LGD-4033LGD-4033: Phase 2 (2 human studies)Phase 2RAD-140RAD-140: Phase 1/2 (1 human study)Phase 1/2AC-262AC-262: Preclinical (0 human studies)PreclinicalACP-105ACP-105: Preclinical (0 human studies)PreclinicalAndarine (S4)Andarine (S4): Preclinical (0 human studies)PreclinicalIGF-1 LR3IGF-1 LR3: Preclinical (0 human studies)PreclinicalMOTS-cMOTS-c: Preclinical (0 human studies)PreclinicalRAD-150RAD-150: Preclinical (0 human studies)PreclinicalS-23S-23: Preclinical (0 human studies)PreclinicalSR9009SR9009: Preclinical (0 human studies)PreclinicalTB-500TB-500: Preclinical (0 human studies)PreclinicalYK-11YK-11: Preclinical (0 human studies)Preclinical

Source: Sarmguide compound database.

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Tools built on this data

New to the topic? Start here for what SARMs are, what the evidence shows and the main risks.

Frequently asked questions

Which SARM has the most human research?

OstarineEvidence: Trial

Ostarine (enobosarm, MK-2866) reached Phase 3: two lung cancer trials with about 650 patients were completed in 2014 but missed their main goals. Smaller trials found about 1 to 1.5 kg more lean mass than placebo at 1 to 3 mg a day.

Read the full section

Is any SARM approved as a medicine?

NoEvidence: Law

No SARM has been approved anywhere in more than 25 years of development. In the US, the FDA says products sold as SARMs are unapproved drugs, not dietary supplements.

Read the full section

Is MK-677 a SARM?

No, a GH secretagogueEvidence: Law

MK-677 (ibutamoren) acts on the ghrelin receptor to raise growth hormone and IGF-1; an FDA briefing document calls it a GHS, not a SARM. It is in the database because it is sold next to SARMs.

Which compounds lowered testosterone the most in studies?

LGD-4033 has the clearest signalEvidence: Trial

In a 21-day trial in young men, LGD-4033 lowered total testosterone and SHBG with dose, and free testosterone and FSH at 1 mg a day. Ostarine lowered total testosterone by about 6 to 7 nmol/L in older men; for RAD-140, suppression data come only from monkeys.

How current is the data?

Data last checked 30 October 2026Evidence: Limited

The whole dataset was last checked on 30 October 2026. A record and its date are updated when a trial reports, a regulator acts or the WADA List changes.

Read the full section

Sources

  1. GTx, Inc. Provides Corporate Update And Reports 2013 Financial Results (press release, 4 March 2014) 2014
  2. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial 2011 · PMID 22031847
  3. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial 2013 · PMID 23499390
  4. Veru Announces Positive Topline Data from Phase 2b QUALITY Clinical Study: Enobosarm Preserved Lean Mass in Patients Receiving WEGOVY (Semaglutide) for Weight Reduction (press release, 27 January 2025) 2025
  5. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet 2017 · PMID 29183075
  6. Selective Androgen Receptor Modulators (SARMs) in Sport: Patterns of Use, Product Contamination, Health Risks and Doping-Control Implications 2026 · PMID 42919612
  7. FDA: Certain bodybuilding products put consumers at risk for heart attack, stroke, serious liver damage and more (content current as of 2 December 2025) 2025
  8. FDA Briefing Document, Pharmacy Compounding Advisory Committee, 29 October 2024: Ibutamoren Mesylate 2024
  9. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men 2013 · PMID 22459616
  10. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140 2011 · PMID 24900290
  11. WADA: The Prohibited List (2026 List, in force from 1 January 2026) 2026