RAD140 (Testolone) Review: Research, Results, Dosage and Side Effects

RAD-140 (testolone) is an experimental, nonsteroidal SARM whose official drug name is now vosilasarm. Its only published human trial tested it as a breast cancer drug in 22 women, where liver-enzyme rises were the most common side effect; no study has measured muscle, strength or body fat in people (LoRusso 2022). It is not approved anywhere, and WADA bans it in sport at all times (WADA 2026).

Below: every RAD-140 study we found, what they show about muscle, side effects and testosterone, the doses studies used, its legal status, and links to all of our RAD-140 guides.

What is RAD-140 (testolone)?

RAD-140 is a selective androgen receptor modulator: a drug that binds the same androgen receptor as testosterone but was designed to act more on muscle and bone than on tissues such as the prostate. It was first described in 2011 (Miller 2011) and comes from Radius Health, whose SARM patent covers it (US patent 8,629,167). The same molecule goes by several names: RAD140, testolone, vosilasarm and the trial code EP0062 (PubChem CID 44200882). UK Anti-Doping also lists “Radarine” as a name it is sold under (UK Anti-Doping).

In rats, a muscle used to test androgens (the levator ani) responded from 0.03 mg/kg, with less effect on the prostate (Miller 2011). That kind of tissue selectivity is what made SARMs interesting, but a 2026 review notes that it is reproducible in animals and small in humans, and that no SARM has been approved in more than 25 years (Adolf 2026). RAD-140’s developer path today is cancer, not muscle: Ellipses Pharma is testing it as EP0062 in a Phase 1/2 trial in advanced breast cancer (Ellipses Pharma 2024; NCT05573126).

RAD-140 research at a glance

Human studies come first. Animal and cell results are labeled as such: they show what a drug can do in a model, not what it does in people.

See how RAD-140’s research stage compares with other compounds in the SARMs database.

Does RAD-140 build muscle? What the evidence shows

Muscle and strength in people: never tested

No human trial has measured muscle, strength or body composition with RAD-140. The completed Phase 1 trial was a cancer study (NCT03088527), and the anti-doping studies only measured urine levels (Wagener 2022). Every claim about RAD-140 and muscle in people therefore rests on user reports, not measurements.

Muscle in animals: mostly positive, one negative study

In rats, RAD-140 increased the weight of the levator ani muscle, and in young male monkeys 28 days raised body weight by more than 10% (Miller 2011). A 2025 rat study found larger muscle fibers after 14 days (Puskas 2025). The one study in female mice went the other way: 10 weeks raised frailty and mortality risk and did not improve strength (Brown 2023).

Fat loss: not established

No human study has measured body fat with RAD-140. The weight loss and low appetite seen in about a quarter of Phase 1 patients occurred in people with advanced cancer and are listed there as side effects (LoRusso 2022).

RAD-140 results and before-and-after reports

Because no study has measured results in healthy people, before-and-after photos cannot separate RAD-140’s effect from training, diet, other drugs or a mislabeled product. For comparison, SARMs that were tested in randomized trials added roughly 1 to 1.5 kg of lean mass (Adolf 2026). Our RAD-140 before and after page collects user reports next to that context, and the older 8-week RAD-140 log is one user’s account. For timing questions, see when do SARMs kick in.

RAD-140 side effects

The table lists what has been documented, from the strongest evidence to the weakest. Case reports describe single patients, often using several products, so they cannot prove that RAD-140 alone caused the problem.

The FDA says life-threatening reactions, including liver injuries that needed hospital care, have occurred in people taking SARM products (FDA). For every side effect across all SARMs, see SARMs side effects and are SARMs liver toxic?

RAD-140 with MK-677

Several of the case reports above involved MK-677 (ibutamoren) as well: the breast-growth case (Chong 2024) and the spleen rupture (Jaffry 2026). A 47-year-old bodybuilder who took RAD-140, andarine and ibutamoren for 3 months developed blood sugar of 558 mg/dL and needed insulin; his doctors thought ibutamoren played the main role (Sotorník 2022). MK-677’s own risks are covered in MK-677 side effects, and the combination in MK-677 and RAD-140 stack.

Gyno, hair loss, acne and blood pressure

No study has looked at hair loss, acne or blood pressure with RAD-140, and the case reports in our sources do not describe them. The one breast-growth case involved undeclared hormones (Chong 2024). What is known about each across SARMs: RAD-140 gyno, do SARMs cause gyno?, SARMs and hair loss, SARMs and acne, SARMs and blood pressure and SARMs and alcohol.

Does RAD-140 suppress testosterone?

Probably, although no trial has measured it in men. In young male monkeys, 28 days of RAD-140 lowered testosterone from about 600–800 to about 200–300 ng/dL (Miller 2011). In the human trial, SHBG fell in every patient measured, a sign that the drug was acting on androgen receptors (LoRusso 2022). Case reports describe low testosterone in men whose products contained RAD-140 together with other drugs (Chong 2024).

How fast hormones recover after RAD-140 has not been studied. With LGD-4033, another SARM, testosterone and SHBG were back to baseline about 5 weeks after a 21-day trial ended (Basaria 2013). After longer cycles of anabolic steroids, testosterone recovered within 3 months in most men, but sperm counts took about a year and 11% still had low testosterone at the end of follow-up (Smit 2021).

More detail: RAD-140 suppression, RAD-140 PCT, PCT after SARMs, do SARMs lower testosterone? and do SARMs shrink your balls? The PCT and bloodwork planner lists the tests and the PCT drugs that have been studied.

Bloodwork: the markers that changed in studies

Liver enzymes, bilirubin and SHBG changed in the RAD-140 trial. Testosterone, FSH, SHBG and HDL cholesterol are the markers that changed in trials of other SARMs (Basaria 2013). These are the tests that track those changes:

• ALT and AST (liver enzymes) and bilirubin
• Total and free testosterone, LH and FSH
• SHBG
• Lipid panel (HDL and LDL cholesterol)

What each test means and when it is usually taken: SARMs bloodwork guide and low testosterone blood test.

RAD-140 dosage: what studies used

The only human treatment doses on record are from the Phase 1 trial: 50, 100 or 150 mg a day in women with advanced breast cancer, where 100 mg/day was the highest dose tolerated (LoRusso 2022). No study has tested any dose of RAD-140 for muscle or performance in healthy people, so there is no evidence-based “muscle dose”. The anti-doping studies used micro-doses of 1 to 50 µg to study detection, not effects (Wagener 2022).

Products are sold by label strength. SwissChems, for example, sells RAD-140 as 10 mg capsules. For liquids, how many mL a dose is depends entirely on the concentration printed on the bottle (mg per mL); no study has tested liquid RAD-140. Our RAD-140 dosage guide sets trial doses next to what users report, and liquid SARMs covers liquids, pills and powders.

RAD-140 half-life

About 45 hours (44.7 h), measured in the Phase 1 trial at 50–150 mg/day (LoRusso 2022). It is the only human pharmacokinetic figure published, and it may differ in men or at lower doses. At that half-life, roughly 70% of a dose is still in the body 24 hours later, which is why the question of morning or night matters less for RAD-140 than for short-acting drugs; no study has compared dosing times.

Is RAD-140 legal?

• United States: not FDA-approved. The FDA says products containing SARMs are illegally marketed, unapproved drugs, not dietary supplements (FDA). SARMs are not federally scheduled: a 2019 bill to schedule them was introduced and sent to committee, and GovInfo holds no later version (GovInfo).
• United Kingdom: UK Anti-Doping lists vosilasarm (RAD-140, Radarine, testolone) among SARMs, says no SARM is approved for human use anywhere, and notes that the Food Standards Agency treats SARMs as unauthorized novel foods, so they are illegal to sell or advertise as food or in supplements (UK Anti-Doping).
• Australia: SARMs are prescription-only (Schedule 4) and listed in Appendix D clause 5, so possession without authority such as a prescription is illegal (Poisons Standard 2026).
• Germany: the annex to the Anti-Doping Act names “RAD-140, synonym Testolon” (AntiDopG annex). The Act bans trading in listed substances for doping in sport and acquiring or possessing a “non-small quantity” for doping in sport (AntiDopG §2).
• Prescription or pharmacy: RAD-140 is not an approved medicine in any country we could find (LoRusso 2022), so there is no prescription or pharmacy version anywhere.

Country by country: are SARMs legal?, SARMs in Europe and SARMs in Australia.

RAD-140 in sport and drug tests

WADA lists RAD140 by name under S1.2 (other anabolic agents) and prohibits it at all times (WADA 2026). Testing is very sensitive: a single 50 µg micro-dose was found in urine for up to 29 days (Wagener 2022), and 50 µg rubbed on the forearm was detected for up to 9 days (Korsmeier 2025). RAD-140 was one of the three SARMs most often found in a study of urine samples from men outside sport (Bohlin 2024). See SARMs and WADA, SARMs drug test and how long SARMs stay in your system.

RAD-140 vs other SARMs

Head-to-head pages: RAD-140 vs LGD-4033, ostarine vs RAD-140, YK-11 vs RAD-140 and RAD-140 vs RAD-150. Or put any two side by side with the compare tool.

RAD-140 stacks

No study has tested RAD-140 combined with another compound for muscle or fat loss. What exists are case reports of people who took combinations: cholestatic liver injury with RAD-140 plus LGD-4033 (Barbara 2020), breast growth and low testosterone with RAD-140, MK-677 and cardarine (Chong 2024), and diabetes-level blood sugar with RAD-140, andarine and ibutamoren (Sotorník 2022). Combining drugs that each affect the liver, hormones or blood sugar makes it harder to know which one caused a problem.

Our stack pages: RAD-140 stacks, RAD-140 and cardarine and MK-677 and RAD-140. The stack checker shows where the documented risks of any combination overlap.

Buying RAD-140: is it what the label says?

Often not, across the SARM market. When researchers bought 44 products sold online as SARMs, only 52% contained a SARM at all, 39% contained a different unapproved drug, 9% contained no active compound and 41% matched the amount on the label (Van Wagoner 2017). In almost all published SARM liver-injury cases, the product itself was never analyzed (Adolf 2026).

If you buy, look for a lot-specific certificate of analysis from an independent lab and learn how to read a lab test. Our current pick is SwissChems, which publishes lot-specific lab reports; the reasons and its weak points are in our SwissChems review, and where to buy SARMs explains what to check with any seller.

Bottom line

RAD-140 is a breast cancer drug candidate, not a tested muscle builder. Its one human trial found liver-enzyme rises in about half of patients, and liver injury is also the most common serious harm in case reports from people using it for muscle. The muscle data come from rats and three monkeys per group, and one mouse study was negative. It probably lowers testosterone, it is banned in sport and detectable for weeks, and it is illegal to sell as a supplement in the US, UK and Australia. Anyone weighing it up should know those facts first and keep an eye on liver and hormone blood tests with a doctor.