Growth hormone (GH) is one of the most important compounds in humans, helping with the replication, regeneration, growth and development of every cell in your body.
This write-up introduces a peptide hormone, analogue and secretagogue of GH called CJC-1295.
In this CJC-1295 review, you will learn:
- What is CJC-1295
- Types of CJC-1295
- The benefits of CJC-1295
- CJC-1295 dosage and cycle length
- CJC-1295 side effects
- Where to buy the purest CJC-1295
- …and much more!
CJC-1295 is a synthetic peptide developed by ConjuChem Biotechnologies.
To properly explain CJC-1295, we first have to understand Sermorelin acetate, which is also a peptide; an analogue of GHRH (Growth Hormone Releasing Hormone) to be precise.
GHRH is used to gauge how much Growth Hormone is released by the body and is helpful in determining growth hormone deficiency.
The scientists at ConjuChem were looking to improve Sermorelin acetate in order to help patients suffering from insufficient amounts of GH.
After some experimenting, they created CJC-1295, a peptide with higher bioavailability and half-life compared to its predecessor.
The nickname of CJC-1295 should tell you all about its potency, it’s also called DAC:GRF, which stands for drug affinity complex : growth hormone-releasing factor.
Interestingly enough, CJC-1295 is composed of 29 amino-acids, which is almost twice as much as BPC-157, a popular peptide used for healing and wound tending.
How Does It Work
CJC-1295 has numerous effects on the body but it mainly works by stimulating the pituitary gland to release more GH and IGF-1, increasing serum concentration levels in the body by a marked amount.
Increased GH levels are often correlated with increase in lean body mass, better sleep, reduced inflammation, neuroprotective properties and increased Testosterone production.
Increased IGF-1 levels are associated with increased muscle mass, decreased fat levels and regenerative properties.
In humans, GH is secreted between eight to ten times per day, rhythmically.
CJC-1295 increases both the strength of the release, as well as decreasing the action of somatostatin, which is a growth hormone inhibitor.
Types of CJC-1295
There are two main types of CJC-1295 you see on the market, with or without DAC.
DAC stands for Drug Affinity Complex and was also developed by ConjuChem, so it’s not something a vendor or a third person is adding to the peptide.
Supposedly, CJC-1295 with DAC promises higher shelf life, longer half-life and better bioavailability.
On the other side of the coin, some people are concerned that CJC-1295 with DAC overloads the pituitary gland too soon, leading to GH resistance or even GHI (Growth Hormone Insensitivity).
Note that no study insofar has found any of the above to be true; quite on the contrary, both versions of CJC-1295 were tolerated quite well in both animal and human studies.
We don’t think you should concern yourself with what type you’re getting, they are both from the same company and they are both perfectly safe.
Is CJC-1295 Legal
In most countries, including the US, CJC-1295 is in a gray area, legally speaking.
It’s not yet approved for human consumption by the FDA, so it’s being marketed as a research compound.
This means that you can purchase CJC-1295 online without any problems but only as a research chemical for scientific purposes.
However, buyers should beware, as some countries have special laws governing peptides.
For example, in Denmark, peptides such as CJC-1295 have been confiscated and their use was described as ‘illicit’.
This is just one country out of many and shouldn’t concern you much but to be perfectly safe, check the local laws of your state/country.
CJC-1295 In Sports
Ten years ago, when nobody in the WADA paid much attention to peptides, it was basically a free-for-all.
Nowadays, the situation has changed drastically.
The WADA and USADA acknowledge the potent effect peptides such as CJC-1295 can have on the body and have since banned the compound.
In fact, Sport Integrity Australia has a special page dedicated just to CJC-1295, where offenders that have used or distributed the peptide are publicly named.
In the WADA handbook, CJC-1295 is considered prohibited and put under section ‘S2’, which denotes ‘peptide hormones, growth factors, related substances and mimetics’.
This should tell you all about the unfair advantages athletes get when they imbue peptides such as CJC-1295.
Speaking of advantages, let’s list the benefits of this peptide!
The release of GH and IGF-1 has so many benefits in the human body that an entire book wouldn’t suffice to cover the topic.
We’ll name the four biggest benefits tied to CJC-1295 alone and briefly mention the secondary perks of this peptide at the end of the section.
1. CJC-1295 Aids Fat Loss
Even if you’re not a bodybuilder, fat storages in your body can lead to serious diseases if in high enough concentrations over extended periods of time.
A study done on GHRH-KO mice showed that administering CJC-1295 once daily helped normalize prolactin levels, which are associated with fat loss, even in human subjects.
Prolactin slows down your overall metabolism which can lead to fat and plaque accumulating in your blood, leading to cardiovascular disease.
Luckily, even if you’re suffering from high prolactin levels, CJC-1295 has been shown to quickly regulate its levels, leading to a reduced chance of problems occurring down the road.
2. CJC-1295 Increases IGF-1 Levels
We’ve already mentioned all the benefits of increased IGF-1 levels but we didn’t say a word about the possible side effects of elevated IGF-1 levels.
The interesting thing is, CJC-1295 does not change the body’s pulsatile (rhythmic) IGF-1 secretion timing, which means that usual side effects associated with IGF-1 simply don’t occur.
However, what has to be noted is that researchers were expecting the compound to be even stronger in its effects on IGF-1 levels (only a 40% increase was observed, instead of the expected 75%).
Despite that, no side effects is a far better trade off compared to higher IGF-1 levels, which means that CJC-1295 passes the test with flying colors.
3. CJC-1295 Increases GH Secretion
Our growth hormone is responsible for growth all over the body and its function doesn’t stop once our teenage years are over.
Moreover, it affects bone density, muscle mass, fat storage (especially around the stomach) and cholesterol levels.
CJC-1295 increases serum concentration levels of GH in the human body by up to 50%.
4. High Bioavailability Compared To Other GH Secretagogues
A compound can show excellent results in cellular and even animal studies but if it’s not absorbed by the human body at a high enough rate, it all amounts to nothing.
CJC-1295 is one of the most bioavailable GH secretagogues available on the market.
The company behind this peptide used recent advances in molecular biology, utilizing a process called bioconjugation.
Bioconjugation happens when two molecules are fused together, in this case, two proteins, in order to increase stability, bioavailability and drug tolerability.
If you thought this was it when it comes to the benefits of CJC-1295, you haven’t even seen half of it.
More than 100 studies have shown that GHRH analogues (such as CJC-1295) have the following additional benefits in the human body and mind:
- Improved cardiovascular function
- Increased muscle mass
- Increased fat loss
- Neuroprotective properties
- Nootropic effects
- Better mood and decreased depression
- Wound healing and tissue repair
- Improved recovery times
- Increased protein synthesis
- Better sleep
- Better skin, nails, hair
- …and a whole lot more!
Over 90% of CJC-1295 entering the body ends up binding to albumin, a liver protein which transmits this peptide throughout the body.
Not just that, it also prevents CJC-1295 from escaping your bloodstream and therefore, CJC-1295 has one of the longest half-lives of all the peptides.
Although no study mentions the exact half-life of CJC-1295, it’s estimated to be around seven days.
CJC-1295 Dosage And Cycle Length
Peptides are usually consumed in miniscule levels, such as micrograms (not to be confused with milligrams!).
Since CJC-1295 is usually injected and has a long half-life, you won’t need to use it more than once a week to feel the full range of effects.
Studies on humans are sparse but from the literature available; especially a study performed in 2006, dosages between 30 to 60 mcgs per kg of body weight were tolerated quite well and no adverse effects were found.
What does this mean for a fully grown human?
Say you weigh 90kg and are opting for the low end of the spectrum to keep things safe.
You would multiply 90 by 30mcgs and get 2700mcgs of CJC-1295 per week.
Ensure that you’re using a precise measuring tool if you’re consuming liquid CJC-1295.
While no overdoses have been reported, it’s best to not test the waters when it’s not necessary.
Last but not least, it’s important to note that CJC-1295 accumulates in the body over time, so one thing can’t be stressed enough; you have to cycle it!
A twelve week CJC-1295 cycle followed by a month of no peptides at all should do the trick, according to anecdotal reports.
The best time to take CJC-1295 would be before going to bed, as it can cause increased hunger in subjects who’re imbuing it.
CJC-1295 Side Effects
The study we mentioned above was performed on healthy human volunteers and they experienced no side effects at all from CJC-1295 usage.
That is to be expected due to the fact that it doesn’t strain the pituitary gland as much as other GH secretagogues.
However, some anecdotal reports point to side effects seen in first time users and in those who took too much at once.
If you’re feeling like the room is spinning or are having headaches after you imbue CJC-1295, you should lower your dosage.
However, if it’s your first time taking CJC-1295, it’s just your body reacting to a foreign substance it has never met before.
These side effects go away after just a couple of doses and should not concern the user.
2. Increase In Body Temperature
A very rare side effect experienced when the user takes too much CJC-1295 to begin with.
No medical intervention is needed as it goes away on its own.
3. Mood Swings
Another rare side effect, most prominent in those already suffering from psychiatric disorders (especially mood disorders).
If you have a history of mental illness, consult your local healthcare provider before starting CJC-1295 or any other peptide.
Peptides like CJC-1295 can interact with certain medications and make them less effective or in some cases, more potent.
CJC-1295 VS Ipamorelin
Vendors often offer these two peptides together in a stack.
Is that done to increase revenue or is there really a benefit to stacking them together?
In our opinion, it’s not necessary to stack CJC-1295 with Ipamorelin since both of these peptides are strong enough on their own and exert potent effects on the body.
One downside of stacking both of these peptides is the increased risk of side effects, although both compounds are generally considered to be safe and well-tolerated.
To conclude, it’s best to pick one of them and stick with your decision, as consuming multiple GH secretagogues at once could lead to overstimulation of the pituitary gland.
Where to Buy CJC-1295
No doctor is going to bother prescribing CJC-1295 to their patients, so the best and fastest way to obtain CJC-1295 is to buy it online.
Buying peptides online can be a giant headache, since there are literally hundreds of options to choose from.
If you were to do your due diligence, it would take you months, maybe even years, to find a vendor worthy of consideration.
Luckily for you, our team of experts has bought and tested CJC-1295 from dozens of vendors.
While most of them didn’t pass our rigorous testing routines, there are a couple out there that are doing things right.
To get the best and purest form of CJC-1295, check out our recommended list of peptide companies.
It’s an exhaustive list of legitimate peptide companies that care and respect the integrity and anonymity of their customers.
All in all, this CJC-1295 review has shown you all you need to know about this peptide.
While there haven’t been a lot of human studies performed with CJC-1295, it’s a very promising peptide due to its high bioavailability, half-life and potent effects.
It’s one of our favorite GH secretagogues due to the fact that it doesn’t produce the usual side effects experienced when imbuing such compounds.