Short answer: the eight RAD-140 (testolone) before and after reports below are unverified accounts of 6–8 week cycles; the muscle figures the original article gave were guesses from photos. No study has ever measured muscle or strength with RAD-140 in people. Its only human trial was in women with advanced breast cancer, where liver-enzyme rises were the most common side effect (LoRusso 2022). In young male monkeys, 28 days raised body weight by more than 10% and cut testosterone by roughly two-thirds (Miller 2011).
Below: what the research shows, how to read user reports, and the reports themselves, framed as what each person said, not as measured results.
RAD 140 Summary
RAD-140 (testolone, now named vosilasarm) is a nonsteroidal SARM first described in 2011. It is not approved anywhere we could find; it is being tested again as EP0062 in a breast cancer trial (NCT05573126).
| Question | What is known | Evidence |
|---|---|---|
| Muscle in humans | Never measured | None |
| Muscle in animals | Rats: muscle response from 0.03 mg/kg with less effect on the prostate; monkeys: body weight up more than 10% in 28 days (Miller 2011). Rats: bigger muscle fibers after 14 days (Puskas 2025). Female mice: more frailty, no strength gain (Brown 2023) | Animal |
| Testosterone | Monkeys: about 600–800 down to 200–300 ng/dL in 28 days; not measured in men | Animal |
| Liver | Phase 1: AST up in 59% and ALT in 45%, serious rises in 23% (50–150 mg/day); several cholestatic liver-injury case reports in users | Trial; case reports |
| Heart | Case reports of myocarditis and heart failure in young men; cause not proven (myopericarditis case 2024) | Case reports |
| Half-life | About 45 hours | Trial |
59%
AST up in Phase 1
45%
ALT up
23%
serious rises (50–150 mg/day)
Note
The old version of this page called RAD-140 “safe and effective” with manageable side effects. The evidence above does not support that. Full details are in the RAD-140 fact sheet.
What the studies show: realistic RAD-140 timelines
There is no human RAD-140 timeline for muscle, because no trial measured it. What the research does give is a timeline for the measured effects:
| Time point | What was measured | Study |
|---|---|---|
| 2–6 hours | Peak in urine after a micro-dose (healthy men) | Wagener 2022 |
| About 1 week | Steady levels with daily dosing (half-life 44.7 h, once daily) | LoRusso 2022 |
| 14 days | Bigger muscle fibers in young male rats | Puskas 2025 |
| 28 days | Monkeys: body weight +10% or more; testosterone down by about two-thirds | Miller 2011 |
| Weeks to months | Liver-enzyme rises in women with cancer; liver-injury case reports in users after weeks to months | LoRusso 2022, Niazi 2025 |
| Dose studied | Who took part | Duration | What the study found | Source |
|---|---|---|---|---|
| 50, 100 or 150 mg/day | Postmenopausal women with heavily pretreated ER+/HER2- metastatic breast cancer (n=22) | Daily until disease progression (median progression-free survival 2.3 months) | Open-label Phase 1 dose-escalation (3+3) with a pharmacokinetic expansion The maximum tolerated dose was 100 mg/day. AST rose in 59% and ALT in 45% of patients; serious (grade 3/4) AST/ALT rises occurred in 23%. One patient had a partial response. SHBG fell in all 18 patients measured. | PubMed 2022 |
Sources: the studies linked in the table.
- Photos are not measurements. The original version of this page put muscle numbers on these reports by judging photos; those guesses have been removed. A photo cannot separate muscle from water, fat loss, a pump, lighting or posture. For scale, tested SARMs added about 1.2–1.3 kg (3 lb) of lean mass in trials (LGD-4033 and ostarine).
- Three of the eight are stacks (MK-677, cardarine or SR9009).
- Five of the eight reported no SERM afterwards and none reported bloodwork. In monkeys, testosterone fell by about two-thirds; in men it has not been measured, so how suppressed these readers were, and whether they recovered, is unknown.
- User doses (5–20 mg) are far below the 50–150 mg tested in the cancer trial, but that trial is the only human safety data, and liver changes were common there.
RAD-140 Before and After Results (User Reports)
Editor’s note: these eight reports come from the original version of this article. They are unverified individual reports: who sent them, what was in the bottle, the doses and the results could not be checked, and the original photos are no longer available. The muscle and body-fat figures the original author estimated from the photos have been removed. The cycles are what each person said they took, not recommendations, and the outcomes are not typical or expected results.
Every person below also trained and dieted during the cycle, and three used other compounds, so no change can be credited to RAD-140 alone. Readers can send their own reports through the contact page.
RAD 140 Results #1
This reader reported more muscle in the upper body and more visible veins after RAD-140 alone. The size of any gain was not measured; the photo-based figure from the original article has been removed.
Reported use: RAD-140 alone for 8 weeks, no PCT, as the person described it; not a recommendation. Not verified.
Testosterone suppression with RAD-140 has not been measured in men; see RAD-140 PCT for what is known.
RAD 140 Results #2
This reader was already lean at the start and reported small changes in shoulder and chest size and vascularity. He said he felt suppressed near the end of the cycle; no bloodwork was reported, so that cannot be checked.
Reported use: RAD-140 alone for 8 weeks, then clomiphene (Clomid) for 4 weeks, as the person described it; not a recommendation. Not verified.
RAD 140 Results #3 (+ MK-677)
This reader stacked RAD-140 with MK-677 and reported a large change in arm size. MK-677 adds body weight and water in trials, so part of a fuller look can be fluid, and the photo-based weight figure from the original article has been removed.
Reported use: RAD-140 with MK-677 for 8 weeks, then MK-677 alone for 4 more weeks, as the person described it; not a recommendation. Not verified.
MK-677 does not restore testosterone; in obese men it lowered total testosterone vs placebo (Svensson 1999). One man using MK-677 with RAD-140 had a spontaneous spleen rupture, a link the authors call speculative (Jaffry 2026). More: MK-677 as PCT.
RAD 140 Results #4 (+ Cardarine)
This reader reported a body recomposition: more muscle and less fat at the same time, while dieting. With cardarine and a diet in the mix, fat loss in a photo says little about RAD-140, and the original estimates of fat lost and muscle gained were guesses from photos, now removed.
Reported use: RAD-140 with cardarine for 8 weeks, no PCT, as the person described it; not a recommendation. Not verified.
See the RAD-140 and cardarine stack for what is known about each part.
RAD 140 Results #5
This reader ran a shorter first cycle because of concern about side effects and reported none. He described modest changes in chest, arm and shoulder size; none were measured.
Reported use: RAD-140 alone for 6 weeks, no PCT, as the person described it; not a recommendation. Not verified.
Warning
Reporting no side effects is not the same as having none: liver enzymes and testosterone were not tested, and those are where problems showed up in research.
RAD 140 Results #6
This reader used RAD-140 during a bulk with a planned diet and reported more size and less body fat.
Reported use: RAD-140 alone for 8 weeks, then clomiphene (Clomid) for 4 weeks, as the person described it; not a recommendation. Not verified.
See Clomid PCT for what studies show about clomiphene.
RAD 140 Results #7 (+ Stenabolic)
This reader used RAD-140 with stenabolic during a cut and reported losing weight and body fat while keeping muscle. A leaner body can also look more muscular without any gain.
Reported use: RAD-140 with stenabolic (SR9009) for 8 weeks, no PCT, as the person described it; not a recommendation. Not verified.
Stenabolic (SR9009) has never been tested in people; see SR9009 dosage.
RAD 140 Results #8
This reader took the highest dose of the eight and reported more muscle and less body fat. The original article itself called this cycle potentially dangerous.
Reported use: RAD-140 alone for 8 weeks, then clomiphene (Clomid) for 6 weeks, as the person described it; not a recommendation. Not verified.
Recovery after RAD-140 has not been studied.
My RAD 140 Results
Editor’s note: this is the original author’s personal account from the earlier version of this site. It is one person’s unverified experience without bloodwork or body-composition scans, not a measured result or a recommendation.
The author reported taking RAD-140 alone for 8 weeks and no PCT.
Strength
The author’s main report was a large strength increase, first noticed around week two. No study has measured strength with RAD-140 in people, so this cannot be compared with trial data.
Muscle Gain
The author reported gaining muscle gradually over the 8 weeks and estimated about a pound a week, without a scan to separate muscle from water. No human study has measured muscle gain with RAD-140.
What the study found: Miller 2011
- Population
- monkeys
- Duration
- 28 days
- Result
- Body weight rose more than 10%
Fat Loss
The author reported losing belly fat during the cycle. No measurement method was given, and the cycle was combined with training and diet; fat loss with RAD-140 has not been studied in people.
Vascularity
The author reported more visible veins. Vascularity depends heavily on body fat, a pump and lighting, so it is not a measure of muscle gain.
The only side effect the author reported was irritability. Testosterone was not tested, so whether this dose suppressed it is unknown; in young male monkeys, RAD-140 cut testosterone by about two-thirds in 28 days (Miller 2011).
Tips To Get The Best Results
- Expect less than the photos. No human study has measured RAD-140 gains; tested SARMs added about 3 lb of lean mass in trials.
- Timing doesn’t matter much. With a 45-hour half-life, a consistent daily time is enough; see RAD-140 morning or night.
- Check your liver. Liver-enzyme rises were the most common side effect in the only trial, and cholestatic liver injury is reported in users (Perananthan 2024). A liver panel before and during use catches problems early; see are SARMs liver toxic.
- Check your hormones. Testosterone, LH, FSH and lipids before and after; the PCT and bloodwork planner lists them.
- Quality. If you buy, choose a shop with third-party lab reports for each batch; our current pick is in the SwissChems review.
Conclusion
The RAD-140 before and after results on this page are unverified individual reports of large, fast changes in 6–8 weeks, and the original numbers were guesses from photos. The research can’t confirm any of it. RAD-140 has never been tested for muscle in people; in monkeys it added weight but cut testosterone by about two-thirds, and in its only human trial liver-enzyme rises were common. Case reports of liver injury and heart inflammation in users add to that. Compare it with compounds that have human muscle data in the SARMs database, or side by side in RAD-140 vs LGD-4033.
Frequently asked questions
What results can you expect from RAD-140?
Never measured in peopleEvidence: Limited
No human study has measured muscle, strength or fat with RAD-140, and the user reports here are unverified, with gains judged from photos. In monkeys, 28 days of RAD-140 raised body weight by more than 10%.
When does RAD-140 kick in?
Unknown for muscle or strengthEvidence: Trial
Blood levels reach a steady state after about a week of daily dosing, because the half-life is about 45 hours. When muscle or strength changes appear in people has never been measured.
Does RAD-140 cause gyno?
Not establishedEvidence: Human data
One man developed breast growth after supplements labeled RAD-140, MK-677 and cardarine, but lab tests also found undeclared testosterone, estradiol and growth hormone in them; it resolved after stopping.
Does RAD-140 suppress testosterone?
Not measured in menEvidence: Animal
In young male monkeys, 28 days cut testosterone from about 600–800 to 200–300 ng/dL. Case reports in men describe low testosterone after products containing RAD-140 with other compounds.
Is RAD-140 bad for the liver?
Liver-enzyme rises were commonEvidence: Trial
In its only human trial, AST rose in 59% and ALT in 45% of patients, with serious rises in 23%. Several case reports describe cholestatic liver injury in people using RAD-140 products; most recovered after stopping.
Is RAD-140 banned in sport?
Yes, at all timesEvidence: Law
WADA names RAD140 among the SARMs prohibited at all times, and a single 50 µg micro-dose was detectable in urine for up to 29 days.
Sources
- A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer
- Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140
- Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density
- RAD140 (Testolone) negatively impacts skeletal muscle adaptation, frailty status and mortality risk in female mice
- Human In Vivo Metabolism and Elimination Behavior of Micro-Dosed Selective Androgen Receptor Modulator RAD140 for Doping Control Purposes
- Cholestatic Drug-Induced Liver Injury From Rad-140 Successfully Treated With Corticosteroids
- Severe liver injury following use of RAD-140, a selective androgen receptor modulator, for body building
- Myopericarditis Following Use of Selective Androgen Receptor Modifier "RAD-140"
- Acute Myocarditis From the Use of Selective Androgen Receptor Modulator (SARM) RAD-140 (Testolone)
- Reversible Gynecomastia and Hypogonadism Due to Usage of Commercial Performance-Enhancing Supplement Use
- Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review
- Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677
- ClinicalTrials.gov NCT05573126: Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER2-/ER+ Breast Cancer
- WADA: The Prohibited List (2026 List, in force from 1 January 2026)