RAD140 PCT Guide: Do You Need a PCT After Testolone?

RAD140 (testolone) is treated as one of the more suppressive SARMs, but the human data are thin. No trial has measured testosterone in men taking it. In young male monkeys, 28 days of RAD140 lowered testosterone from about 600–800 to about 200–300 ng/dL (Miller 2011). In the only human trial, in women with breast cancer, SHBG fell in every patient measured, a sign of androgen activity (2022).

No study has tested PCT after RAD140. So whether a PCT is needed is something a blood test shows, not a rule. Below: what RAD140 is, what PCT is, the suppression evidence, the “no PCT” cycles people describe, and what is known about Nolvadex and Clomid after RAD140.

What is RAD140?

RAD140 is a non-steroidal SARM. Older versions of this page said no human studies existed; that changed with a Phase 1 trial in 22 postmenopausal women with advanced ER+ breast cancer, published in 2022 (2022). It is now being tested as EP0062 (vosilasarm) in a breast cancer trial (NCT05573126). No trial has tested muscle, strength or body composition in people.

What the Phase 1 trial found (50–150 mg/day): the maximum tolerated dose was 100 mg/day; AST rose in 59% and ALT in 45% of patients, with serious (grade 3/4) rises in 23%; bilirubin rose in 27% (2022). Case reports describe cholestatic liver injury after weeks to months of RAD140 (2026) and heart-muscle inflammation in young men, without proof of cause (2024).

Older versions of this page listed reduced prostate size as a benefit and said users typically gain 7–10 pounds of muscle in eight weeks. No human study supports either claim. Full profile: RAD140 (Testolone) review.

What is a PCT?

When androgen-receptor activity rises, the brain lowers LH and FSH and the testes make less testosterone. After a cycle, it takes time for that chain to restart. PCT (post-cycle therapy) means drugs taken to speed that up: SERMs such as tamoxifen and clomiphene, sometimes hCG or an aromatase inhibitor. A 2026 review found the evidence for PCT limited and mostly observational, and noted that most users recover on their own (Smit 2026).

Do you need a PCT for RAD140?

The evidence on RAD140 and testosterone, in full:

On our 0–3 scale RAD140 scores 2 (moderate), with low confidence because the main data are from animals. More: RAD-140 suppression and SARMs PCT (all compounds compared).

Older versions of this page gave a rule of thumb: under about 6 mg/day no PCT, above it PCT. That came from user experience; no study has tested any RAD140 dose in men. Product quality also matters: in a 2017 analysis of 44 products sold as SARMs, only 52% contained a SARM and only 41% the labeled amount (Van Wagoner 2017).

The only way to know is a blood test: total testosterone (fasting, morning), free testosterone, SHBG, LH and FSH, plus liver enzymes and bilirubin because of RAD140’s liver signal (Bhasin 2018). RAD140’s half-life is about 45 hours (measured in women) (2022); after five half-lives about 3% is left (StatPearls), so test about 9 days after the last dose. A baseline test before the cycle makes the result readable. See SARMs bloodwork and the PCT & Bloodwork Planner.

How long does recovery take after RAD140?

Nobody has measured it. The nearest data points: after 21 days of LGD-4033 at up to 1 mg/day, hormones were back to baseline five weeks after the last dose (Basaria 2013). After anabolic steroids, testosterone was back within about 3 months for most men, sperm took about a year, and 11% still had low testosterone at one year (Smit 2021). In 641 men at a UK clinic, only 48.2% had fully normal LH, FSH and testosterone on a single test up to 36 months after stopping steroids (Grant 2023). Low testosterone in men can show up as low sex drive, muscle loss and breast enlargement (MedlinePlus), but a blood test is what confirms it.

No PCT RAD140 cycle

Older versions of this page described a “no PCT” RAD140 cycle of no more than 5 mg/day for eight weeks, dropping to 2.5 mg/day if suppressed. That is anecdotal. The facts that bear on it:

• No human study has used RAD140 at 2.5–10 mg/day; the only trial used 50–150 mg/day in women with cancer (2022).
• In monkeys, suppression was clear within 28 days (Miller 2011).
• With a ~45-hour half-life, RAD140 takes about 9 days to clear after the last dose.

No dose of RAD140 has been shown to avoid suppression.

PCT after RAD140: what is known

Older versions of this page recommended Clomid over Nolvadex for RAD140 and gave four-week protocols by dose. No study has tested PCT after RAD140, or compared Clomid with Nolvadex after any SARM. What exists:

RAD140 PCT with Nolvadex

Tamoxifen raises LH and testosterone in men with a working hormone axis, and it also raises SHBG, so free testosterone rises less than total (Birzniece 2010). It has a half-life of 5–7 days and a metabolite of about 14 days, so it stays in the body for weeks (label). Whether it speeds recovery after RAD140 has not been tested. Doses, side effects and legal status: Nolvadex PCT.

Conclusion

RAD140 very likely suppresses testosterone in men: it did so strongly in monkeys, it lowered SHBG in every woman measured, and case reports describe low testosterone in men. But no trial has measured it in men, no dose is known to be safe from suppression, and no PCT has been tested after it. RAD140 also carries a real liver signal. A blood test about nine days after the last dose, compared with a baseline, is the only way to know where you stand. Related: RAD 140 dosage, RAD 140 gyno, RAD 140 before and after.