WADA 2027 Prohibited List: What Changes for SARMs, Peptides and PCT Drugs

The World Anti-Doping Agency’s 2027 Prohibited List comes into effect on 1 January 2027, and its main change for readers of this site is about peptides. WADA now names peptides as examples in section S0 (non-approved substances) and warns that a peptide can be prohibited even if it is not named. The list also adds the “exercise mimetic” compounds SLU-PP-332 and SLU-PP-915 and the PPAR-delta agonist seladelpar to the metabolic modulators, and adds imlunestrant to the anti-estrogens. Everything that was banned stays banned: SARMs, MK-677, BPC-157, TB-500 and the PCT drugs remain prohibited at all times.

The changes that matter here

What did not change

The 2027 List keeps the same named entries for the compounds we cover: SARMs such as ostarine (enobosarm), LGD-4033, RAD-140, S-23 and YK-11 under S1.2; MK-677, ipamorelin, CJC-1295 and tesamorelin under S2.2.4; IGF-1 analogs and TB-500 under S2.3; aromatase inhibitors such as anastrozole under S4.1; and SR9009, cardarine and MOTS-c under S4.4.1. All are prohibited in and out of competition. SARMs not named on the list, such as RAD-150, are covered by the class wording.

Other changes

Outside the compounds we cover, WADA clarified how metabolites of substances of abuse are handled, updated the cannabinoid section to reflect current knowledge of THC-like effects (cannabidiol itself is still not prohibited), added vaginal administration as a permitted route for glucocorticoids, and removed codeine, hydrocodone, dermorphin and, out of competition, fentanyl and tramadol from the monitoring program.

What it means for athletes

The peptide wording is the practical change. Many products are sold as “research peptides” with names that do not appear on the list. WADA’s position for 2027 is explicit: an unapproved peptide is likely prohibited anyway, and may be harmful. Contamination is a real risk too: anti-doping studies have detected SARMs in urine after doses of a few micrograms, the kind of amount a contaminated supplement can contain. See SARMs and WADA and SARMs drug test.