RAD-140 Stack: Common Combinations and What Is Known

Short answer: the most common RAD-140 (testolone) stacks are with ostarine for cutting, MK-677 for bulking, cardarine for strength and endurance, and SR9009 plus andarine for a recomp. None has been studied. RAD-140’s only human trial was in women with advanced breast cancer, where liver-enzyme rises were the most common side effect (LoRusso 2022); in young male monkeys it cut testosterone by about two-thirds in 28 days (Miller 2011). Every compound you add brings its own risks, so check combinations with the stack checker.

The original author of this page described RAD-140 as strong enough on its own and advised newcomers not to stack it; that view is kept below, with what the research shows for each partner compound. Full profile: RAD-140 fact sheet.

Practices to Avoid When Stacking RAD 140

The first thing to keep in mind is to not forgo having a PCT supplement nearby, in case you experience something more than mild suppression while on a RAD 140 stack.

Whether RAD-140 needs a PCT in men is unknown, because testosterone has not been measured in men taking it; the monkey data suggest strong suppression. See RAD-140 PCT.

Another thing to avoid is to stack RAD 140 with SARMs that are suppressive in their nature.

For example, I’ve read logs where people stacked YK11 and RAD 140, wondering why they went into a complete shutdown four weeks into their cycle.

This is your body we’re talking about here and you should be conscious of the fact that stacking two highly suppressive SARMs can only lead to disaster.

Besides YK11, avoid Ligandrol and S23.

LGD-4033 lowered total testosterone at doses as low as 0.1 mg a day over 21 days (Basaria 2013), and S-23 cut LH by more than half in rats (Jones 2009). YK11’s effect has never been measured. Stacking two androgen-receptor drugs adds suppression from both.

Users usually keep cycles to about eight weeks; no study has tested RAD-140 for any length of time in healthy people.

RAD 140 Stack For Cutting

Evidence level: anecdotal. No RAD-140 stack has been studied, and RAD-140 itself has never been tested for muscle in people. The doses below are what users commonly report, kept from the original article; they are not a protocol.

Commonly reported: ostarine 10 mg plus RAD-140 5 mg a day for eight weeks, with a SERM such as Nolvadex kept on hand. Users report 3–4 lb of muscle kept or gained, about 5% body fat and 10 lb of weight lost on a calorie deficit.

What is known about ostarine: in 120 adults over 60, 3 mg a day for 86 days added 1.3 kg lean mass vs placebo, lowered HDL by 27% and, in men, lowered total testosterone (Dalton 2011). The old claim that ostarine “makes your bones strong enough” for new muscle has no human evidence and was removed. More: ostarine stacks.

RAD 140 Stack For Bulking

Evidence level: anecdotal. No RAD-140 stack has been studied, and RAD-140 itself has never been tested for muscle in people. The doses below are what users commonly report, kept from the original article; they are not a protocol.

Commonly reported: RAD-140 5 mg plus MK-677 10 mg a day for eight weeks. Users report about 10 lb of muscle and 15 lb of weight, and say MK-677’s hunger helps them eat more.

What is known about MK-677: it is not a SARM. In a 12-month trial in older adults, increased appetite was its most common side effect (67% vs 36% on placebo), with water retention and higher fasting glucose (Nass 2008). It does not protect testosterone: in obese men it lowered total testosterone vs placebo (Svensson 1999). One man using MK-677 with RAD-140 had a spontaneous spleen rupture, a link the authors call speculative (Jaffry 2026). More: MK-677 fact sheet.

RAD 140 Stack For Body Recomping

Evidence level: anecdotal. No RAD-140 stack has been studied, and RAD-140 itself has never been tested for muscle in people. The doses below are what users commonly report, kept from the original article; they are not a protocol.

Commonly reported for experienced users only: andarine (S4) 25 mg twice a day, RAD-140 5 mg and Stenabolic (SR9009) 30 mg a day split into three doses before 5 pm, for eight weeks.

What is known about the partners:

• Andarine: no published human trials; its half-life is 2.6–5.3 hours in rats (Kearbey 2004), not the 8 hours quoted in the old version. Users report vision changes at higher doses. See S4 before and after.
• SR9009: never tested in people; human half-life unknown (the old “4–6 hours” has no source). In mice, REV-ERB agonists increased wakefulness (Banerjee 2014), which is why users avoid evening doses, and SR9009 has been linked to acute liver failure in a 17-year-old (Shams Bin Shaheen 2026). See SR9009 dosage.

Three compounds, two of them never tested in people, means three sets of unknowns. Claims that this stack needs no PCT are guesses.

RAD 140 Stack For Strength

Evidence level: anecdotal. No RAD-140 stack has been studied, and RAD-140 itself has never been tested for muscle in people. The doses below are what users commonly report, kept from the original article; they are not a protocol.

Commonly reported: RAD-140 5 mg plus cardarine 10 mg a day for eight weeks, taken in the morning. Users report strength gains and new personal bests.

What is known about cardarine: it is not a SARM and has no strength data in people; endurance gains were shown in mice (Narkar 2008). Human trials of 2–12 weeks improved blood fats. GSK stopped its development after two-year animal studies found cancers in many organs (GSK letter, 2013). Full details: RAD-140 and cardarine stack.

Conclusion

RAD-140 is stacked with ostarine, MK-677, cardarine, andarine and SR9009, but none of those combinations has been studied, and RAD-140 itself has no human muscle data. The partners bring their own documented effects: lower testosterone and HDL with ostarine, appetite, water and blood sugar with MK-677, animal cancer findings with cardarine, and untested human use with andarine and SR9009. Liver-enzyme rises were the most common side effect of RAD-140 in its trial, so a liver panel and hormone bloodwork before and after are the minimum. Compare the compounds in the SARMs database and see RAD-140 vs LGD-4033 and YK11 vs RAD-140.