My 12-Week MK-677 Log: Week-by-Week Results

This is a week-by-week MK-677 log from the original author of Sarmguide: 12 weeks at 12.5 mg a day taken before bed, with weight going from 76 to 82 kg, hunger that faded after the first weeks, and better sleep. It is one person’s experience. Below the log, we compare it with what controlled human trials measured, so you can see which parts match the research and which don’t.

The log is kept as the author wrote it. For the compound itself, see our MK-677 (ibutamoren) review; for doses studied, MK-677 dosage.

MK-677 summary

MK-677 (ibutamoren) is often mistaken for a SARM, but it is a growth hormone secretagogue: it copies the hormone ghrelin and makes the pituitary release more growth hormone (GH), which raises IGF-1 (FDA 2024). As LUM-201 it is in a Phase 3 trial for children with GH deficiency (NCT06948214); it is not approved as a medicine anywhere we could find.

Sources: Nass 2008, Copinschi 1997, Adunsky 2011. The older summary on this page listed fat loss, more strength and faster hair and nail growth as benefits, and said diabetes was only possible “if taken for multiple years”; the trials don’t support those claims, and blood sugar rose within weeks (Chapman 1996). Full details: MK-677 side effects.

The 12-week log

Editor’s note: the original author’s log, unchanged. The dose is what he took, not a recommendation.

My constant dose of MK-677 was 12.5mg a day. I took the dose before bed.

Week 1-2

In the first two weeks of the cycle, my body weight increased from 76kg to 78kg.

At first, especially in the first week, I felt an increased hunger which subsided during the second week. Occasionally, there would be an increase in resting heart rate and increased sensitivity to heat.

The main thing that I noticed in the first two weeks was a big improvement in my sleep quality. I was fully rested even after only 6 hours of sleep. Muscle growth is already somewhat visible.

Week 3-4

In the third and fourth week, my weight dropped from 78kg to 77kg. The hunger, which started to subside towards the end of last week, subsided even more in the third and I no longer felt increased hunger in the fourth week.

The quality of sleep was good. Hair and nails started to grow a lot faster and I also felt like my hair got thicker. At the end of the fourth week, I noticed a slighty better body recomposition – increased definiton, and increased muscle mass compared to the beginning of the cycle.

Week 5-6

In the fifth and sixth week of my MK-677 cycle, my body weight increased from 77kg to 79kg. Increased hunger could no longer be felt.

The quality of sleep and skin was good. Again, an increase in muscle mass is also noticeable.

Week 7-8

In the seventh and eigth week, my body weight increased a bit at the beginning and then stabilized at 80kg. Skin and sleep quality have improved.

My weight wasn’t changing much but my fat to muscle ratio was improving.

Week 9-10

In the ninth and tenth week, my weight rose from 80kg to 81kg. Hunger still occurred occasionally, but the onset of hunger was very mild.

The quality of sleep has improved. If I compare the quality of sleep after the tenth week to the quality of sleep before the cycle, I find that 6 hours of sleep now works for me like 9 hours of sleep before the start of the cycle. Muscle growth in this two-week period was a lot more noticeable than in the weeks prior.

Week 11-12

In the last two weeks, my body weight has increased a bit more, from 81kg after the tenth week to 82kg after the end of the cycle.

The quality of the skin, hair and nails was great. My skin and hair was glowing. Muscle growth was also very noticeable, especially when compared to my pictures from the start of the cycle. I didn’t gain that much weight but my fat to muscle ratio improved nicely.

Conclusion and my opinion

Summarizing my cycle of taking MK-677, I find that with very few or side effects, I have gained a lot of muscle mass. In fact, the only side effect that I experience was an increase in hunger and even that subsided after the first few weeks.

I also noticed that my sleep was a lot better as well as nails, skin and hair., better sleep, and better skin quality. Overall, I’m happy with this cycle, it resulted in a nice body recomposition. I’d say that I gained a few lbs of muscle and lost a few lbs of fat over these 12-weeks.

I recommend taking frequent pictures of yourself if you track anything like this. This way, you will be able to easily track your progress.

How this log compares with the trials

Two other points. The author took 12.5 mg, about half the 25 mg most trials used, and no trial has tested 12.5 mg/day for 12 weeks. And the log has no blood tests, so it can’t show what happened to glucose, IGF-1 or liver enzymes, the markers trial investigators watched (FDA 2024). For more user-reported results, see MK-677 before and after results.