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Compare SARMs and Peptides Side by Side

Pick two compounds and see half-life, research stage, WADA status, testosterone suppression, liver signal, strength of evidence and reported side effects side by side.

Key takeaways

  • Compare any two compounds in the database on ten rows, each linked to its source.
  • Suppression, liver and evidence are 0 to 3 scores from the cited studies; side effects carry evidence labels.
  • Values come from separate studies, not head-to-head trials, so compare them with care.
  • Comparisons are shareable links, for example ?a=ostarine&b=lgd-4033.

Pick two compounds to see them side by side: what type of compound each is, its half-life, how far it got in clinical trials, its WADA status, how much it lowered testosterone in studies, its liver signal, the strength of the evidence and the side effects studies reported. Every cell comes from the Sarmguide database and links to its source.

SR9009 compared with Cardarine
SR9009Cardarine
TypeOtherOther
ClassREV-ERB agonist (body-clock and metabolic modulator)PPARδ agonist (metabolic modulator)
Half-lifeNot establishedNot established
Research stagePreclinical sourcePhase 2 source
Human studies04
Approved as a medicineNoNo
WADA (sport)Prohibited at all times sourceProhibited at all times source
Testosterone suppressionNot measured Not established. SR9009 is not a hormone and does not act on the androgen receptor. No study has measured testosterone with it. sourceNot measured Cardarine is not a hormone and does not act on the androgen receptor. The published human trials did not report testosterone, so there are no human data either way. source
Liver signalModerateMild
Strength of evidenceVery limitedModerate
Side effects reported
  • Acute liver failure needing a transplant case report source
  • Liver injury case report source
  • Hidden in products sold as SARMs lab analysis source
  • Cancer in rats animal source
  • Cancer in mice animal source
  • Faster growth of intestinal polyps animal source
  • Long-term effects in humans unknown regulator warning source
  • Liver damage and muscle breakdown (with ostarine) case report source
  • Hormone problems from contaminated products case report source
Markers studies trackedALT/AST (liver enzymes), Bilirubin, INR (blood clotting)Lipid panel (HDL, LDL, triglycerides), ALT/AST (liver enzymes), Fasting glucose and insulin, CK (creatine kinase)

Sarmguide is reader-supported. We may earn a commission from partner links. How we earn These listings are separate from the research above: they are the same whatever the result shows and are not a recommendation.

How the comparison works

Each row is read from the compound’s database record, the same data that powers its fact sheet. A small source marker next to a value links to the study or document behind it. “Not established” means we found no reliable human data, not that the risk is zero.

The suppression, liver and evidence rows are Sarmguide scores from 0 to 3, based on the cited studies; suppression is marked “human data” or “animal data”, and “Not measured” when there are no data. The side-effects row lists up to six findings with their evidence label (trial, case report, animal and so on), so a trial finding and a single case report never look the same.

After the table, a separate section headed “Where to buy (affiliate links)” shows the partner shop’s listings for the two compounds. It is the same whatever the table shows and is not a recommendation.

You can share a comparison: the page address keeps your choice, for example ostarine vs LGD-4033 or MK-677 vs tesamorelin.

What a side-by-side table cannot show

  • It lines up separate studies; it is not a head-to-head trial. Studies differ in dose, length and who took part (older adults, cancer patients, young men), so numbers in two columns are not directly comparable.
  • Half-lives come from different study designs. RAD-140’s figure (about 45 hours) comes from a trial in women with advanced breast cancer (LoRusso 2022); LGD-4033’s (24 to 36 hours) from healthy young men (Basaria 2013).
  • It does not cover combinations. For that, use the stack checker.

Written comparisons

For the most searched pairs we have full articles with the studies, the side effects and the reader reports in context:

Frequently asked questions

Is cardarine a SARM?

NoEvidence: Law

Cardarine (GW501516) is a PPAR-delta agonist, and WADA lists it under S4.4.1, not with the SARMs in S1.2. Its developer stopped work on it after cancers appeared in rats and mice at all doses tested.

Which is better studied, ostarine or RAD-140?

Ostarine, by farEvidence: Trial

Ostarine reached Phase 3 and has several controlled trials with results. RAD-140 has one published human trial, in 22 women with advanced breast cancer, and its muscle data come from animals.

Do RAD-140 and LGD-4033 have the same half-life?

NoEvidence: Trial

RAD-140's half-life was about 45 hours in women with advanced breast cancer; LGD-4033's was 24 to 36 hours in healthy young men. The groups differ a lot, so treat the gap as approximate.

Read the full section

Can I share a comparison?

YesEvidence: Limited

The page address keeps your choice (for example /compare/?a=ostarine&b=lgd-4033), so you can bookmark or send it.

Read the full section

Sources

  1. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer 2022 · PMID 34565686
  2. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men 2013 · PMID 22459616
  3. WADA: The Prohibited List (2026 List, in force from 1 January 2026) 2026
  4. WADA issues alert on GW501516 (21 March 2013) 2013
  5. Rat carcinogenicity study with GW501516, a PPAR delta agonist (Geiger et al., The Toxicologist 2009, abstract 895) 2009
  6. GTx, Inc. Provides Corporate Update And Reports 2013 Financial Results (press release, 4 March 2014) 2014
  7. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial 2011 · PMID 22031847