Short answer: there is no researched YK11 dosage. YK11 has never been given to people in a clinical study, so no dose has been tested for effect or safety. The doses users commonly report are 5–15 mg a day for 4–8 weeks, usually followed by a SERM such as Clomid because they expect testosterone suppression. Those numbers are anecdotal.

This page sets out what is known, what users report for bulking and cutting, and what has never been measured. The original author’s experience is in YK11 before and after results.

YK11 Summary

YK11 is a synthetic steroid that behaves like a SARM: in cell tests it was a partial agonist of the androgen receptor (Kanno 2011). In mouse muscle cells it raised follistatin, a protein that blocks myostatin, and that is the basis for calling it a “myostatin inhibitor” (Kanno 2013). That effect has only been shown in cells.

What you need for a dose Status for YK11
Human dose-finding study None
Half-life in humans Not established
Effect of dose on testosterone Not measured
Safety data Rat studies only: brain oxidative stress and inflammation after 5 weeks (Dahleh 2023)
Product strength Unverified; SARM products are often mislabeled (JAMA 2017)

More in our YK11 review; compounds with human dosing data are compared in the SARMs database.

YK11 Half-Life

The half-life of YK11 is not established. No pharmacokinetic study has been published in humans or animals. In an elimination study run for doping control, no intact YK11 appeared in urine at all; unconjugated breakdown products were gone within 24 hours, while conjugated ones were traceable for more than 48 hours (Piper 2018).

24 hours

unconjugated breakdown products gone within

48 hours

conjugated ones traceable for more than

Note

Users often guess the half-life at around 12 hours and split the daily amount into a morning and an afternoon dose. That guess has no study behind it. Why that matters: without a half-life, nobody knows how long YK11 stays active or how quickly it clears after a cycle.

YK11 Bulking Dosage + Example Cycle

Evidence level: anecdotal. No YK11 dose has been tested in a human study, so every number in this section comes from user reports, not research. It describes what people say they took; it is not a recommendation.

For a bulk, users most often report 10–15 mg a day for about 8 weeks, eating above maintenance, followed by a few weeks of Clomid. This pattern appeared in most of the reader reports on our before and after page:

Reported pattern (anecdotal) YK11 After the cycle
Weeks 1–8 10–15 mg/day /
Weeks 9–12 / Clomid (users report 50 mg, then 25 mg/day)

Users run a SERM afterwards because they expect their own testosterone to be suppressed; with YK11 that has never been measured. For what studies show about clomiphene itself, see Clomid PCT.

YK11 Cutting Dosage + Example Cycle

Evidence level: anecdotal. No YK11 dose has been tested in a human study, so every number in this section comes from user reports, not research. It describes what people say they took; it is not a recommendation.

On a cut, users typically report a lower 5–10 mg a day for 6–8 weeks, again followed by Clomid. Claims of gaining 2–3 lb of lean mass during a cut come from user reports only.

Reported pattern (anecdotal) YK11 After the cycle
Weeks 1–8 5–10 mg/day /
Weeks 9–12 / Clomid (users report 25 mg/day)

Many cutting stacks pair YK11 with cardarine; read YK11 stacks for what is known about each part.

No PCT YK11 Dosage?

There is no known “no-PCT” dose of YK11, because nobody has measured what any dose does to testosterone, LH or FSH. Some users try 5 mg a day or less to avoid PCT and still report symptoms of low testosterone afterwards; that is anecdotal too.

Nolvadex (tamoxifen), a SERM used for PCT

For comparison, a SARM that has been tested, LGD-4033:

What the study found: Basaria 2013

Dose
just 1 mg a day
Duration
21 days
Result
lowered total testosterone

The only way to know where you stand is bloodwork before and after; the PCT and bloodwork planner lists the markers.

Safest YK11 Dosage

Warning

No YK11 dose has been shown to be safe, because no dose has been studied in people. The rat studies used large doses for five weeks and found brain inflammation, oxidative stress and memory problems (Dahleh 2023, Dahleh 2024); they do not tell us what a lower dose does.

What is reasonable to say: lower doses and shorter use expose you to less of an unknown drug, and bloodwork is the only way to see suppression, cholesterol or liver changes. Liver injury has been reported with several SARMs in healthy adults (Vignali 2023); see are SARMs liver toxic.

Product quality matters as much as the number on the label: if the capsule does not contain what it says, the dose is meaningless. If you buy, choose a shop that publishes a third-party lab report for each batch; our current pick is explained in the SwissChems review.

What YK11 Dosage Should I Take

We can’t give you a YK11 dose, and nobody can give you a researched one. Users commonly describe starting at 5 mg a day and staying at or under 15 mg; that is the range in the reports above, not a tested range.

A few practical points that don’t depend on YK11 research:

  • Liquids: the dose depends on the concentration printed on the bottle. At 10 mg per ml, 0.5 ml contains 5 mg and 1 ml contains 10 mg. Check the label rather than assuming.
  • Injectable YK11: no injectable form has been studied at all.
  • Women: there are no YK11 data for women at all.
  • Compare first: if your goal is muscle, the database shows which compounds have human trials, and YK11 vs LGD-4033 puts the two side by side.

How YK11 doses compare with tested SARMs

The SARMs that have been in human trials were dosed very differently from each other, which is why a number cannot be borrowed from one compound for another:

Compound Doses tested in people Who and how long Source
LGD-4033 0.1, 0.3 and 1 mg/day 76 healthy young men, 21 days Basaria 2013
LGD-4033 (VK5211) 0.5, 1 and 2 mg/day 108 adults aged 65+ after hip fracture, 12 weeks NCT02578095
Ostarine 0.1–3 mg/day 120 adults over 60, 86 days Dalton 2011
RAD-140 50–150 mg/day 22 women with advanced breast cancer LoRusso 2022
YK11 None Never tested in people No study

The 5–15 mg a day users report for YK11 is therefore not anchored to any trial. Dosing pages for compounds with human data: LGD-4033 dosage, Ostarine dosage and the RAD-140 dosage guide.

Conclusion

Every YK11 dosage you will read, including the bulking and cutting numbers on this page, comes from user reports. YK11 has never been tested in humans, its half-life and effect on testosterone are unknown, and the only safety data come from rats. If you still look at YK11, treat 5–15 mg a day as what people report rather than what is proven, get bloodwork before and after, and know what is actually in the product.

Frequently asked questions

What is the dosage of YK11?

No researched dosageEvidence: Limited

YK11 has never been tested in a human clinical study, so no dose is proven safe or effective. Doses quoted online are anecdotal user reports.

Read the full section

How much YK11 per day do bodybuilders take?

Unverified user reports onlyEvidence: User reports

User reports most often give 5–15 mg a day. These figures are self-reported and unverified, and not anchored to any trial.

Read the full section

What is the half-life of YK11?

Not establishedEvidence: Human data

No pharmacokinetic study exists; an anti-doping study found no intact YK11 in urine, and breakdown products were traceable for more than 48 hours. The often-quoted 12 hours is a user estimate.

Read the full section

Should YK11 be split into two doses a day?

Not studiedEvidence: Limited

Some users split it because they assume a short half-life, but no half-life has been measured. Neither once-daily nor split dosing has been studied.

Read the full section

Do you need PCT after YK11?

Unknown from researchEvidence: Limited

YK11's effect on testosterone has never been measured, while tested SARMs such as LGD-4033 lowered it at 1 mg a day. Bloodwork is the only way to know.

Read the full section

How many ml of liquid YK11 is a dose?

Depends on the label concentrationEvidence: Limited

At 10 mg/ml, 1 ml contains 10 mg. Liquid products are often mislabeled, so the true amount can differ.

Read the full section

Is there a safe YK11 dosage?

No dose shown to be safeEvidence: Animal

The only safety studies are in rats, where five weeks of YK11 caused oxidative stress, inflammation and memory problems in the hippocampus.

Read the full section

Sources

  1. (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor 2011 · PMID 21372378
  2. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression 2013 · PMID 23995658
  3. Studies on the in vivo metabolism of the SARM YK11: Identification and characterization of metabolites potentially useful for doping controls 2018 · PMID 30379415
  4. YK11 induces oxidative stress and mitochondrial dysfunction in hippocampus: The interplay between a selective androgen receptor modulator (SARM) and exercise 2023 · PMID 37468001
  5. From gains to gaps? How Selective Androgen Receptor Modulator (SARM) YK11 impact hippocampal function: In silico, in vivo, and ex vivo perspectives 2024 · PMID 38521455
  6. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men 2013 · PMID 22459616
  7. ClinicalTrials.gov NCT02578095: Acute Hip Fracture Study in Patients 65 Years or Greater (VK5211), posted results 2017
  8. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial 2011 · PMID 22031847
  9. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer 2022 · PMID 34565686
  10. Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users 2023 · PMID 37218811
  11. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet 2017 · PMID 29183075