People like to panic for no reason. Many will claim that SARMs are still new to the market and that we still have no idea about their long-term effects on our bodies.
I mean, SARMs appeared for the first time in 1998, that was 22 years ago and as of now, not one death or cancer diagnosis has been linked to SARMs.
This isn’t just an isolated incident we’re talking about, thousands upon thousands of people have used SARMs, so there are enough ‘test subjects’ to verify the safeness and effectiveness of SARMs.
Also, if twenty years aren’t enough to gouge the long-term effects of a compound, then how long does it take? 50, 100, maybe a million years?
I’m personally frustrated at the major publications for spewing nonsense and fearmongering when it comes to SARMs usage.
One question does pose itself – what is the logic behind SARMs causing cancer and what started it all?
There are two theories as to how SARMs could potentially cause cancer and I will debunk them both in this section of the article.
Overactivation of the Androgen Receptor
The theory goes as follows: If you keep your androgen receptors activated all of the time, the chance for a mutation to occur during gene expression heightens which could lead to cancer.
First of all, cells mutate all the time in our body and that’s why we have our immune system to stop them before they get out of control.
Secondly, there is not one study in the last 70 years since we started ‘overactivating our androgen receptor’ that even shows a remote increase in cancer risk.
Lastly, this would mean that anything binding to the androgen receptor basically poses a risk.
DHT, Testosterone and other androgens are all ‘unsafe’ as they bind to the androgen receptor and cause it to be overactive.
Do you know how many steroid users should have cancer by now if this were to be true?
The only thing that steroids do affect is prostate size which could lead to cancer development.
However, SARMs are tissue-selective and don’t screw with the prostate.
Moreover, it has been shown that SARMs are now being investigated for potentially mitigating the effects cancer has on the prostate.
They are more likely to cure cancer than cause it!
SARMs Cause Cell Growth Which Could Lead To Cancer
This theory could be summed up as: Cancer is basically the unregulated growth of cells and taking drugs that accelerate cell growth can lead to an increase in cancer risk because of potential mutations.
At first glance, this seems like circular reasoning, which is a logical fallacy in itself.
Secondly, SERMs also influence cell growth and they have not been linked to cancer. Raloxifene, for example, has been approved by the FDA and risk of cancer is not amongst its side effects.
Lastly, humans have been using compounds that increase cell growth well over 70 years and still, there is no hint that any of them cause cancer.
Until a study comes out that shows a link between SARMs and cancer, I will not be ceasing use or promotion of the same.
What About Cardarine
First of all, Cardarine isn’t a SARM, it’s a PPAR delta agonist.
The flawed study proving that Cardarine caused cancer used rats that were prone to getting cancer in the first place. I mean, I’ve written enough about it here, and I’m not going to repeat myself.
The main takeaway is that Cardarine, in normal dosages, doesn’t cause cancer in humans.
MK-677, IGF-1 and Cancer
One thing to keep in mind is not to take MK-677 while you have cancer because increase in the expression of the IGF-1 gene could lead to exacerbated cancer growth.
This only applies if you already have cancer, MK-677 is safe otherwise.
In conclusion, you don’t have to worry about getting cancer from SARMs.
There have been so many studies done on humans and not one did find a link between SARMs and cancer.
I have shown and dispelled two common myths propagated around Forums and bodybuilding blogs. Now you have the power to tell people spreading FUD (Fear, uncertainty, and doubt) how stuff really works.
All things considered, there’s nothing to worry about and you may continue taking SARMs as usual.